Interleukins: pathophysiological role in acute pancreatitis

Saira Rafaqat; Dimitrios Patoulias; Amir Hossein Behnoush; Saima Sharif; Aleksandra Klisic

doi:10.5114/aoms/178183

Interleukins: pathophysiological role in acute pancreatitis

Arch Med Sci. 2024 Jan 31;20(1):138-156. doi: 10.5114/aoms/178183. eCollection 2024.

Authors

Saira Rafaqat¹, Dimitrios Patoulias², Amir Hossein Behnoush³, Saima Sharif¹, Aleksandra Klisic^{4

5}

Affiliations

¹ Department of Zoology, Lahore College for Women University, Lahore, Punjab, Pakistan.
² Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, Aristotle University of Thessaloniki, General Hospital "Hippokration", Thessaloniki, Greece.
³ School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁴ University of Montenegro-Faculty of Medicine, Podgorica, Montenegro.
⁵ Center for Laboratory Diagnostics, Primary Health Care Center, Podgorica, Montenegro.

Abstract

Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, and IL-20. The ways to modulate IL activity to reduce inflammation and improve outcomes in individuals with this condition are under investigation. Drugs that target specific ILs might be developed to mitigate the effects of AP.

Keywords: acute pancreatitis; inflammation; interleukins; pathogenesis.