Synthesis of CuSe/PVP/GO and CuSe/MWCNTs for their applications as nonenzymatic electrochemical glucose biosensors

Junaid Yaseen; Farhat Saira; Muhammad Imran; Mehwish Fatima; Hafiz Ejaz Ahmed; Muhammad Zeewaqar Manzoor; Momna Rasheed; Iqbal Nisa; Khalid Mehmood; Zahida Batool

doi:10.1039/d3ra06713k

Synthesis of CuSe/PVP/GO and CuSe/MWCNTs for their applications as nonenzymatic electrochemical glucose biosensors

RSC Adv. 2024 Feb 26;14(10):6896-6905. doi: 10.1039/d3ra06713k. eCollection 2024 Feb 21.

Authors

Affiliations

¹ Institute of Physics, The Islamia University of Bahawalpur Pakistan zahida.batool@iub.edu.pk.
² Nanoscience and Technology Development, National Center for Physics (NCP) Pakistan farhat.saira@ncp.edu.pk.
³ Chemistry Department, Faculty of Science, King Khalid University P.O. Box 9004 Abha 6141 Saudi Arabia.
⁴ Department of Physics, Science Unit, Deanship of Educational Services, Qassim University Saudi Arabia.
⁵ Department of Physics, Government College University Faisalabad Pakistan.

Abstract

Copper selenide (CuSe) is an inorganic binary compound which exhibits metallic behavior with zero band gap. CuSe has multiple applications in electrocatalysis, photothermal therapy, flexible electronic and solar cells. In the current study, copper selenide based nanocomposites CuSe/PVP/GO and CuSe/MWCNTs were synthesized by using the sol-gel method for application as a non-enzymatic glucose biosensor. Different characterization methods were employed, such as X-ray diffraction (XRD), photoluminescence (PL), Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-Vis) spectroscopy, and photoluminescence for determining various aspects of CuSe/PVP/GO and CuSe/MWCNTs nanocomposites including phase formation, functional group analysis, band gaps and morphology. Electrochemical impedance spectroscopy (EIS) showed that the resistances of modified electrode/bare electrode were 12.3 kΩ/17.3 kΩ and 6.3 kΩ/17.3 kΩ for CuSe/PVP/GO and CuSe/MWCNTs nanocomposites, respectively. Cyclic voltammetry showed that both CuSe/PVP/GO and CuSe/MWCNTs nanocomposites are promising biosensors for detection and monitoring of the glucose level in an analyte. The sensitivity and limit of detection are 2328 μA mM^-1 cm^-2/0.2 μM and 4157 μA mM^-1 cm^-2/0.3 μM for CuSe/PVP/GO and CuSe/MWCNTs, respectively. Chronoamperometry confirmed that our nanocomposite was the best sensor for glucose even in the presence of other interferents like ascorbic acid (AA), uric acid (UA) and dopamine (DA).