Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers

Verma Abhinav; Rishabh Mittal; Mathiyazhagan Navaneethakannan; Ahirwar Sonu Singh; Mukherjee Sukhes; Kotnis Ashwin

doi:10.2174/0115665240269082240213115711

Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers

Curr Mol Med. 2024 Feb 22. doi: 10.2174/0115665240269082240213115711. Online ahead of print.

Authors

Verma Abhinav¹, Rishabh Mittal¹, Mathiyazhagan Navaneethakannan¹, Ahirwar Sonu Singh¹, Mukherjee Sukhes¹, Kotnis Ashwin¹

Affiliation

¹ Department of Biochemistry, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal, Madhya Pradesh, India.

PMID: 38409703
DOI: 10.2174/0115665240269082240213115711

Abstract

Non-alcoholic fatty liver disease is a globally prevalent disorder that can rapidly progress if not detected early. Currently, no accepted markers exist for early diagnosis and prognosis of NAFLD. This review describes derangement in major metabolic pathways of lipid, carbohydrate, and amino acids in NAFLD. It suggests that measuring levels of thrombospondin, TyG index, asymmetric dimethylarginine, LAL-A, GLP-1, FGF-21, and GSG index are potential markers for early diagnosis of NAFLD. A single marker may not indicate early NAFLD, and further large-scale studies on correlating levels of Thrombospondin-2, triglyceride-glucose index, and FGF-21 with NAFLD are warranted.

Keywords: Cytokeratin-18; Dyslipidemia; Insulin resistance; MAFLD; Metabolic Derangement; NAFLD; NASH; RNA Splicing; Steatosis TyG index; Thrombospondin.