Internal dosimetry study of [82Rb]Cl using a long axial field-of-view PET/CT

Lorenzo Mercolli; Carola Bregenzer; Markus Diemling; Clemens Mingels; Axel Rominger; Hasan Sari; Sigrid Seibel; Antti Sohlberg; Marco Viscione; Federico Caobelli

doi:10.1007/s00259-024-06660-7

Internal dosimetry study of [⁸²Rb]Cl using a long axial field-of-view PET/CT

Eur J Nucl Med Mol Imaging. 2024 Feb 26. doi: 10.1007/s00259-024-06660-7. Online ahead of print.

Authors

Affiliations

¹ Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. lorenzo.mercolli@insel.ch.
² Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
³ Hermes Medical Solutions, Stockholm, Sweden.
⁴ Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.
⁵ Department of Clinical Physiology and Nuclear Medicine, Päijät-Häme Central Hospital, Lahti, Finland.

PMID: 38407598
DOI: 10.1007/s00259-024-06660-7

Abstract

Purpose: Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like ⁸²Rb.

Methods: We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e., MIRD and voxel dosimetry. The subjects were injected with 407.0 to 419.61 MBq of [⁸²Rb]Cl and were scanned dynamically for 7 min with a LAFOV PET/CT scanner.

Results: Using the MIRD formalism and voxel dosimetry, the absorbed dose ranged from 1.84 to 2.78 μGy/MBq (1.57 to 3.92 μGy/MBq for voxel dosimetry) for the heart wall, 2.76 to 5.73 μGy/MBq (3.22 to 5.37 μGy/MBq for voxel dosimetry) for the kidneys, and 0.94 to 1.88 μGy/MBq (0.98 to 1.92 μGy/MBq for voxel dosimetry) for the lungs. The total body effective dose lied between 0.50 and 0.76 μSv/MBq.

Conclusion: Our study suggests that the radiation dose associated with [⁸²Rb]Cl PET/CT can be assessed by means of dynamic LAFOV PET and that it is lower compared to literature values.

Keywords: Dosimetry; Long axial field-of-view PET/CT; Myocardial perfusion imaging; Rubidium-82.