Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses were isolated from domestic ducks in South Kalimantan, Indonesia, during April 2022. The viruses were genetically similar to those detected in East Asia during 2021-2022. Molecular surveillance of wild birds is needed to detect potential pandemic threats from avian influenza virus.
Keywords: H5N1; HPAI; Indonesia; clade 2.3.4.4b; ducks; highly pathogenic avian influenza A; influenza; respiratory infections; viruses; whole-genome sequencing; zoonoses.