Clinical efficacy of photodynamic therapy of oral potentially malignant disorder

Yin Jing; Rong Shu; Tingting Wu; Dongqi Liu; Xiao Luo; Jun Sun; Fangchun Chen

doi:10.1016/j.pdpdt.2024.104026

Clinical efficacy of photodynamic therapy of oral potentially malignant disorder

Photodiagnosis Photodyn Ther. 2024 Feb 23:46:104026. doi: 10.1016/j.pdpdt.2024.104026. Online ahead of print.

Authors

Yin Jing¹, Rong Shu², Tingting Wu², Dongqi Liu², Xiao Luo², Jun Sun², Fangchun Chen³

Affiliations

¹ Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China; The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering, Chongqing 401147, China.
² Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China; The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China.
³ Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China; The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China. Electronic address: 500118@hospital.cqmu.edu.cn.

PMID: 38403144
DOI: 10.1016/j.pdpdt.2024.104026

Abstract

Objective: To investigate the clinical efficacy of aminovalerate hydrochloride photodynamic therapy (PDT) for oral potentially malignant disorder (OPMD),oral leukoplakia (OLK), along with identifying the influencing factors.Additionally, the study aims to detect the rates of recurrence and malignancy after PDT.

Method: 60 patients with OPMD who received PDT at our hospital from 2006 to 2021 were included in this study. Relevant patient medical data were collected and analyzed using SAS 9.4 software.The Mann-Whitney U test was used to retrospectively analyze the factors influencing clinical efficacy, as well as recurrence rate and malignant transformation rate (MTR) after treatment.

Result: Among the 60 OPMD patients receiving PDT, complete remission in 13 (21.67 %), partial remission in 39 (65.00 %), and no remission in eight (13.33 %), resulting in an overall effective rate of 86.67 %.Fifteen patients experienced relapse, leading to a recurrence rate of 25.00 %. Among these relapses,11 patients occurred within one year after treatment, corresponding to an 18.33 % recurrence rate during that period. Moreover, nine patients developed malignant transformation (MT), resulting in an MTR of 15.00 %. Out of these patients, six individuals developed MT within one year after treatment, resulting in a one-year MTR of 10.00 %.

Conclusion: The study findings indicate that PDT shows promising clinical efficacy in the treatment of OPMD, with relatively limited and tolerable postoperative adverse reactions. However, there remains a certain rate of recurrence and malignancy after treatment. Therefore, close attention should be paid to postoperative monitoring, regular follow-up, and further expansion of the sample size to observe its long-term efficacy.

Keywords: Clinical efficacy; Malignant transformation rate; Oral leukoplakia; Oral potentially malignant disorder; Photodynamic therapy; Recurrence rate.