Characterization of the generic mutant p53-rescue compounds in a broad range of assays

Shujun Xiao; Fangfang Shi; Huaxin Song; Jingyi Cui; Derun Zheng; Hesong Zhang; Kai Tan; Jiaqi Wu; Xueqin Chen; Jiale Wu; Yigang Tang; Yuting Dai; Min Lu

doi:10.1016/j.ccell.2024.01.008

Characterization of the generic mutant p53-rescue compounds in a broad range of assays

Cancer Cell. 2024 Mar 11;42(3):325-327. doi: 10.1016/j.ccell.2024.01.008. Epub 2024 Feb 22.

Authors

Shujun Xiao¹, Fangfang Shi², Huaxin Song², Jingyi Cui¹, Derun Zheng², Hesong Zhang², Kai Tan², Jiaqi Wu², Xueqin Chen², Jiale Wu², Yigang Tang², Yuting Dai³, Min Lu⁴

Affiliations

¹ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
² Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: daiyuting@shsmu.edu.cn.
⁴ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: min.lu@shsmu.edu.cn.

PMID: 38402608
DOI: 10.1016/j.ccell.2024.01.008

Abstract

Dozens of compounds that rescue tumor-associated mutant p53 have been reported. Xiao et al. perform 10 assays to evaluate effectiveness of the mutant p53-rescue compounds side-by-side but do not detect reliable rescue in any assay for the evaluated compounds, except for ATO and its analog PAT.

Publication types

Letter

MeSH terms

Humans
Mutation
Neoplasms*
Tumor Suppressor Protein p53* / genetics

Substances

Tumor Suppressor Protein p53