Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A*3303 and HLA-DPB1*0501

Yaqing Shu; Renliang Huang; Qihui Li; Yi Lu; Junping Yin; Huilu Li; Zhike Lan; Xiujun Zheng; Jinlong Ye; Youming Long; Zhanhang Wang; Li Xiao; Qiaomiao Zhou; Xu Liu; Ying Fu; Hao Chen; Juanjuan Chen; Yanxia Zhou; Juan Zhou; Liting Zhang; Jing Zhou; Ying Jiang; Fuhua Peng; Zhengqi Lu; Frank Petersen; Wei Qiu; Xinhua Yu

doi:10.1002/ana.26899

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A3303 and HLA-DPB10501

Ann Neurol. 2024 May;95(5):901-906. doi: 10.1002/ana.26899. Epub 2024 Feb 24.

Authors

Yaqing Shu¹, Renliang Huang², Qihui Li¹, Yi Lu³, Junping Yin⁴, Huilu Li¹, Zhike Lan⁵, Xiujun Zheng⁶, Jinlong Ye⁵, Youming Long⁷, Zhanhang Wang⁵, Li Xiao¹, Qiaomiao Zhou², Xu Liu⁸, Ying Fu⁹, Hao Chen¹⁰, Juanjuan Chen¹¹, Yanxia Zhou¹², Juan Zhou¹³, Liting Zhang¹⁴, Jing Zhou¹⁵, Ying Jiang¹, Fuhua Peng¹, Zhengqi Lu¹, Frank Petersen¹⁶, Wei Qiu¹, Xinhua Yu^{2

16}

Affiliations

¹ Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
² Department of Genetics and Prenatal Diagnosis, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
³ Department of Neurology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
⁴ Institute of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, Germany.
⁵ Department of Neurology, GuangDong 999 Brain Hospital, Guangzhou, China.
⁶ Department of Neurology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-Sen University, Shantou, China.
⁷ Department of Neurology, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁸ Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
⁹ Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
¹⁰ Department of Neurology, The First Affiliated Hospital Nanchang University, Nanchang, China.
¹¹ Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China.
¹² Department of Neurology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
¹³ Department of Neurology, Chenzhou First People's Hospital, Chenzhou, China.
¹⁴ Department of Neurology, Jiangxi Chest Hospital, Jiangxi, China.
¹⁵ Department of Neurology, Foshan First People's Hospital, Foshan, China.
¹⁶ Division of Pulmonary Immune Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel, Borstel, Germany.

PMID: 38400794
DOI: 10.1002/ana.26899

Abstract

We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA-A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.32-3.06, p = 0.00072, p_adj. = 0.046) and HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36-0.71, p = 0.000048, p_adj. = 0.0062). Moreover, HLA-A*3303 carriers with the disease had a longer hospital stay (p = 0.0005) than non-carriers. This study for the first time provides evidence for a role of genetic factor in the development of autoimmune GFAP astrocytopathy. ANN NEUROL 2024;95:901-906.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Astrocytes* / metabolism
Astrocytes* / pathology
Female
Glial Fibrillary Acidic Protein* / genetics
HLA-A Antigens* / genetics
HLA-DP beta-Chains* / genetics
Humans
Male
Middle Aged

Substances

Glial Fibrillary Acidic Protein
HLA-DP beta-Chains
HLA-DPB1 antigen
HLA-A Antigens
GFAP protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding