Computed tomography (CT) resulted in a diagnostic accuracy of 89.2% and 96.1% for medial and lateral meniscal lesions, respectively, in 109 patients who underwent surgery after a direct CT study of the knee joint for a clinically suspected meniscal lesion. The meniscal lesions were the only pathologic condition found in 59 patients, while in 35 patients they were associated with various lesions of the cruciate ligaments (31 cases) and collateral ligaments (15 cases) and with cystic bursitis (6 cases). In the remaining 15 patients, the menisci were normal, but in eight of these cases, lesions of other knee joint structures were present. If meniscal lesions are clinically suspected, direct CT study of the knee joint may be considered the elective radiologic diagnostic method, rather than the more invasive arthrography. It may also be helpful in selecting patients for diagnostic and therapeutic arthroscopy.