Unraveling the Complex Nexus of Human Papillomavirus (HPV) in Extragenital Keratinocyte Skin Tumors: A Comprehensive Analysis of Bowen's Disease and In Situ Squamous-Cell Carcinoma

Claudio Conforti; Chiara Retrosi; Marina Agozzino; Caterina Dianzani; Ermanno Nardon; Anselmo Oliveri; Eros Azzalini; Stefania Guida; Giovanni Pellacani; Giovanni Di Lella; Franco Rongioletti; Iris Zalaudek; Serena Bonin

doi:10.3390/jcm13041091

Unraveling the Complex Nexus of Human Papillomavirus (HPV) in Extragenital Keratinocyte Skin Tumors: A Comprehensive Analysis of Bowen's Disease and In Situ Squamous-Cell Carcinoma

J Clin Med. 2024 Feb 15;13(4):1091. doi: 10.3390/jcm13041091.

Authors

Affiliations

¹ IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy.
² Dermatology Clinic, Maggiore Hospital, Piazza Ospitale 1, 34125 Trieste, Italy.
³ Department of Plastic, Reconstructive and Cosmetic Surgery, Dermatology Section, Campus Bio-Medico University Hospital, 00128 Rome, Italy.
⁴ Department of Medical Sciences (DSM), University of Trieste, 34149 Trieste, Italy.
⁵ Dermatology Clinic, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy.
⁶ Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00196 Rome, Italy.

Abstract

This comprehensive study delves into the intricate landscape surrounding the role of human papillomavirus (HPV) in extragenital keratinocyte skin tumors, specifically exploring Bowen's disease (BD) and in situ squamous-cell carcinoma (iSCC). Through a multifaceted examination, this research study elucidates the nuanced interplay of HPV, gender dynamics, anatomical site variations, and potential implications for the etiopathogenesis of these malignancies.

Keywords: Bowen’s disease; human papillomavirus; keratinocyte skin tumors; squamous-cell carcinoma.

Grants and funding

This study was partially supported by the project iToBoS, funded by the European Union’s Horizon 2020 research and innovation program under the grant agreement No. 965221.