Unveiling the Role of Endothelial Dysfunction: A Possible Key to Enhancing Catheter Ablation Success in Atrial Fibrillation

Int J Mol Sci. 2024 Feb 15;25(4):2317. doi: 10.3390/ijms25042317.

Abstract

Atrial fibrillation, a prevalent type of arrhythmia, is increasingly contributing to the economic burden on healthcare systems. The development of innovative treatments, notably catheter ablation, has demonstrated both impressive and promising outcomes. However, these treatments have not yet fully replaced pharmaceutical approaches, primarily due to the relatively high incidence of atrial fibrillation recurrence post-procedure. Recent insights into endothelial dysfunction have shed light on its role in both the onset and progression of atrial fibrillation. This emerging understanding suggests that endothelial function might significantly influence the effectiveness of catheter ablation. Consequently, a deeper exploration into endothelial dynamics could potentially elevate the status of catheter ablation, positioning it as a primary treatment option for atrial fibrillation.

Keywords: atrial fibrillation; catheter ablation; endothelial dysfunction; endothelial function; endothelium.

Publication types

  • Review

MeSH terms

  • Atrial Fibrillation*
  • Catheter Ablation* / methods
  • Humans
  • Recurrence
  • Treatment Outcome
  • Vascular Diseases*

Grants and funding

This research received no external funding.