Nanotechnology as a Promising Method in the Treatment of Skin Cancer

Int J Mol Sci. 2024 Feb 10;25(4):2165. doi: 10.3390/ijms25042165.

Abstract

The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use of nanoparticles and may allow for the early detection and monitoring of neoplastic changes and determining the effectiveness of treatment. This article briefly reviews the present understanding of the characteristics of skin cancers, their epidemiology, and risk factors. It also outlines the possibilities of using nanotechnology, especially nanoparticles, for the transport of medicinal substances. Research over the previous decade on carriers of active substances indicates that drugs can be delivered more accurately to the tumor site, resulting in higher therapeutic efficacy. The article describes the application of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles in existing therapies. It discusses the challenges encountered in nanoparticle therapy and the possibilities of improving their performance. Undoubtedly, the use of nanoparticles is a promising method that can help in the fight against skin cancer.

Keywords: carbon nanotubes; drug delivery; liposomes; nanofibers; nanoparticles; polymeric nanocarriers; skin cancers.

Publication types

  • Review

MeSH terms

  • Drug Carriers
  • Drug Delivery Systems / methods
  • Humans
  • Metal Nanoparticles*
  • Nanoparticles* / therapeutic use
  • Nanotechnology / methods
  • Nanotubes, Carbon*
  • Skin Neoplasms* / drug therapy

Substances

  • Drug Carriers
  • Nanotubes, Carbon