MiT family translocation-associated renal cell carcinoma: A report of two cases in children

Indian J Pathol Microbiol. 2024 Apr 1;67(2):469-471. doi: 10.4103/ijpm.ijpm_385_22. Epub 2023 Jul 10.

Abstract

Renal cell carcinoma is uncommon in children and must be distinguished from the more common Wilms' tumor. Here, we present two cases of renal cell carcinoma in children both of whom presented with hematuria. Accurate diagnosis is essential in order to differentiate it from epithelial predominant Wilms' tumor which has vastly different prognosis and treatment. Immunohistochemistry for TFE3 is useful in establishing the diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics
  • Carcinoma, Renal Cell* / diagnosis
  • Carcinoma, Renal Cell* / genetics
  • Carcinoma, Renal Cell* / pathology
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Hematuria / etiology
  • Humans
  • Immunohistochemistry*
  • Kidney Neoplasms* / diagnosis
  • Kidney Neoplasms* / genetics
  • Kidney Neoplasms* / pathology
  • Male
  • Translocation, Genetic*
  • Wilms Tumor / diagnosis
  • Wilms Tumor / pathology

Substances

  • TFE3 protein, human
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors