Primary extranodal NK/T cell lymphoma of stomach: A case report and review of literature

Prashant Mane; Prashant Ramteke; Anand Singh; Ajay Gogia; Saumyaranjan Mallick

doi:10.4103/ijpm.ijpm_275_22

Primary extranodal NK/T cell lymphoma of stomach: A case report and review of literature

Indian J Pathol Microbiol. 2023 Jul 10. doi: 10.4103/ijpm.ijpm_275_22. Online ahead of print.

Authors

Prashant Mane¹, Prashant Ramteke¹, Anand Singh², Ajay Gogia³, Saumyaranjan Mallick¹

Affiliations

¹ Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
² Department of Gastrointestinal Surgery, All India Institute of Medical Sciences, New Delhi, India.
³ Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

PMID: 38391355
DOI: 10.4103/ijpm.ijpm_275_22

Abstract

Extranodal Natural killer/T (NK/T) cell lymphoma nasal type is an aggressive non-Hodgkin lymphoma and has a constant association with Epstein-Barr virus (EBV) infection. Approximately more than 75% cases are located in upper aero-digestive tract, of which stomach is a very rare site. Very few cases of gastric extranodal NK/T cell lymphoma have been reported in the literature. A 22-year-old male patient presented with complaints of abdominal pain and hematemesis. Endoscopy showed a large ulcer in the stomach. Partial gastrectomy done and histopathology showed transmural infiltration by intermediate size atypical lymphoid cells which are immunopositive for CD3, CD56, TIA, EBV-encoded RNA (EBER) and negative for CD4, CD8, CD20. A diagnosis of extranodal NK/T cell lymphoma nasal type was made.