(1) There is growing concern surrounding the adverse effects of prolonged sitting on health, yet its impact on post-exercise recovery remains relatively unexplored. This study aimed to better understand the potential influence of habitual prolonged sitting on recovery time and the unfavorable impact prolonged sitting may have on time to recovery, as assessed by muscle damage and inflammatory markers and an isokinetic dynamometer. (2) Nine college-age men (mean age ± SD = 22.1 ± 3.1 years, body mass = 80.9 ± 15.7 kg, height = 171 ± 9.0 cm, Body Mass Index (BMI) = 27.6 ± 4.9 kg·m2) participated in an exhaustive exercise protocol. Creatine Kinase (CK), Myoglobin (Mb), C-Reactive Protein (CRP), White Blood Cell Count (WBC), Peak Torque (PT), and muscle soreness were measured at baseline and 0, 24, 48, and 72 h post-exercise. Dietary and exercise logs were maintained during the 5-day testing procedure. (3) No significant differences were observed in muscle damage markers (CK [p = 0.068] and Mb [p = 0.128]), inflammatory markers (CRP [p = 0.814] and WBC [p = 0.140]), or PT [p = 0.255]) at any time point. However, a significant positive correlation was found between daily sitting time and the percent increase in CK concentration from 0 h to 72 h (r = 0.738, p = 0.023). Strong correlations were also noted between prolonged sitting and percent change in Mb concentration at 48 h (r = 0.71, p = 0.033) and 72 h (r = 0.889, p = 0.001). There was a significant two-way interaction for time × velocity (p = 0.043) for PT with a simple main effect for time at 60°·s-1 (p = 0.038). No significant associations were detected between daily carbohydrate or protein intake and recovery markers (p > 0.05). (4) The findings suggest minimizing daily sitting time may expedite and potentially aid muscle recovery after an intense exercise bout, although further research is warranted to validate these findings.
Keywords: C-reactive protein; creatine kinase; inflammatory markers; interrupted sitting; myoglobin; prolonged sitting; resistance exercise; white blood cells.