COPD and T2DM: a Mendelian randomization study

Front Endocrinol (Lausanne). 2024 Feb 8:15:1302641. doi: 10.3389/fendo.2024.1302641. eCollection 2024.

Abstract

Introduction: Type 2 diabetes (T2DM) stands as a global chronic illness, exerting a profound impact on health due to its complications and generating a significant economic burden. Recently, observational studies have pointed toward a potential link between Chronic Obstructive Pulmonary Disease (COPD) and T2DM. To elucidate this causal connection, we employed the Mendelian randomization analysis.

Method: Our study involved a two-sample Mendelian randomization (MR) analysis on COPD and T2DM. Additionally, tests for heterogeneity and horizontal pleiotropy were performed.

Results: For the MR analysis, 26 independent single nucleotides polymorphisms (SNPs) with strong associations to COPD were chosen as instrumental variables. Our findings suggest a pronounced causal relationship between COPD and T2DM. Specifically, COPD emerges as a risk factor for T2DM, with an odds ratio (OR) of 1.06 and a 95% confidence interval ranging from 1.01 to 1.11 (P = 0.006). Notably, all results were devoid of any heterogeneity or pleiotropy.

Conclusion: The MR analysis underscores a significant causal relationship between COPD and T2DM, highlighting COPD as a prominent risk factor for T2DM.

Keywords: Chronic Obstructive Pulmonary Disease; GWAS data; Mendelian randomization (MR) analysis; causal relationship; type 2 diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / genetics
  • Humans
  • Mendelian Randomization Analysis
  • Odds Ratio
  • Pulmonary Disease, Chronic Obstructive* / complications
  • Pulmonary Disease, Chronic Obstructive* / epidemiology
  • Pulmonary Disease, Chronic Obstructive* / genetics
  • Risk Factors

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research received funding from the Shenzhen Science and Technology Program Innovation and Entrepreneurship Project (KCXFZ20201221173209027), supported by the Guangdong Provincial Administration of Traditional Chinese Medicine (2022201), and the Shenzhen Traditional Chinese Medicine Hospital's 2021 "3030 Plan" Clinical Research Project (G3030202126).