APOL1-mediated and Mendelian forms of "heretofore" idiopathic collapsing glomerulopathy: lessons from Brazil

Nicholette D Palmer; Barry I Freedman

doi:10.1016/j.kint.2023.12.014

APOL1-mediated and Mendelian forms of "heretofore" idiopathic collapsing glomerulopathy: lessons from Brazil

Kidney Int. 2024 Mar;105(3):437-439. doi: 10.1016/j.kint.2023.12.014.

Authors

Nicholette D Palmer¹, Barry I Freedman²

Affiliations

¹ Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
² Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: bfreedma@wakehealth.edu.

PMID: 38388143
DOI: 10.1016/j.kint.2023.12.014

Abstract

APOL1-mediated kidney diseases have forever changed nephrology and kidney transplantation. Neves et al. extend this field with analyses in admixed Brazilians with the most severe type of APOL1-mediated kidney disease, idiopathic collapsing glomerulopathy. Causative gene variants were detected in 58.6% of patients; 80.5% had APOL1 high-risk genotypes, and 19.5% had causative Mendelian variants. Their work identifies the cause of previous idiopathic collapsing glomerulopathy and provides opportunities to identify novel modifiers in severe APOL1-mediated kidney diseases that are relevant beyond Brazil.

MeSH terms

Apolipoprotein L1 / genetics
Brazil
Humans
Kidney Transplantation*
Renal Insufficiency, Chronic*
South American People*

Substances

Apolipoprotein L1
APOL1 protein, human

Supplementary concepts

Brazilian people