Undescribed cytotoxic bisabosqual-type meroterpenoids from an endophytic Stachybotryaceae sp. associated with Delphinium yunnanense

Hongtao Li; Changyan Li; Cuiping Miao; Yating Shao; Wenyu Huang; Bo He; Wei Li

doi:10.1016/j.phytochem.2024.114037

Undescribed cytotoxic bisabosqual-type meroterpenoids from an endophytic Stachybotryaceae sp. associated with Delphinium yunnanense

Phytochemistry. 2024 Apr:220:114037. doi: 10.1016/j.phytochem.2024.114037. Epub 2024 Feb 20.

Authors

Hongtao Li¹, Changyan Li¹, Cuiping Miao², Yating Shao¹, Wenyu Huang¹, Bo He¹, Wei Li³

Affiliations

¹ School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, PR China.
² Yunnan Institute of Microbiology, Key Laboratory for Southwest Microbial Diversity of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, 650091, PR China.
³ School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, PR China. Electronic address: liwei@kmmu.edu.cn.

PMID: 38387725
DOI: 10.1016/j.phytochem.2024.114037

Abstract

Five undescribed bisabosqual-type meroterpenoids, bisabosquals E (1) and F (2), stachybisbins J-L (4-6), together with two known ones, were isolated from a novel endophytic fungus KMU22001 within the Stachybotryaceae family. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, single-crystal X-ray diffraction and electronic circular dichroism calculations. Compounds 2, 4 and 6 exhibited significant cytotoxicities against five human cancer cell lines with IC₅₀ values ranging from 1.80 ± 0.08 to 17.76 ± 0.97 μM.

Keywords: Bisabosqual-type meroterpenoids; Cytotoxicity; Endophyte; Stachybotryaceae.

MeSH terms

Antineoplastic Agents* / pharmacology
Circular Dichroism
Crystallography, X-Ray
Delphinium*
Humans
Molecular Structure

Substances

Antineoplastic Agents