Wnt, notch signaling and exercise: what are their functions?

Yijie Zhao; Guangjun Wang; Zhifeng Wei; Duo Li; Mohammadamin Morshedi

doi:10.1007/s13577-024-01036-3

Wnt, notch signaling and exercise: what are their functions?

Hum Cell. 2024 Feb 22. doi: 10.1007/s13577-024-01036-3. Online ahead of print.

Authors

Yijie Zhao¹, Guangjun Wang², Zhifeng Wei³, Duo Li³, Mohammadamin Morshedi⁴

Affiliations

¹ Ministry of Public Sports, Hebei North University, Zhangjiakou, 075000, Hebei, China.
² Ministry of Public Sports, Hebei North University, Zhangjiakou, 075000, Hebei, China. xxniu200426@outlook.com.
³ The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, Hebei, China.
⁴ School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. ma.morshedi55555@gmail.com.

PMID: 38386243
DOI: 10.1007/s13577-024-01036-3

Abstract

In the last decade, the study of Wnt and Notch signaling in cell biology has led to significant progress in understanding embryogenesis, bone development, muscle healing, neurogenesis, and tumorigenesis. It has been found that regular physical activity can counteract the decline of skeletal muscle caused by aging, which is linked to osteoporosis, regenerative neurogenesis, hippocampal function, cognitive ability, and the creation of neuromuscular junctions. Despite these discoveries, there is still uncertainty about how cell biology and exercise can impact the Wnt and Notch signaling pathways in the locomotor system. This review aims to summarize the potential influence of exercise on Wnt and Notch signaling.

Keywords: Exercise; Notch signaling; Wnt signaling.

Publication types

Review