Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics

Expert Opin Biol Ther. 2024 Mar;24(3):115-118. doi: 10.1080/14712598.2024.2322062. Epub 2024 Feb 27.

Authors

Lukas Pekar¹, Simon Krah¹, Stefan Zielonka^{1

2}

Affiliations

¹ Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
² Biomolecular Immunotherapy, Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.

PMID: 38385844
DOI: 10.1080/14712598.2024.2322062

No abstract available

Keywords: Antibody; VHH; antibody engineering; bispecific antibody; cytokine; cytokine mimetic; single domain antibody; surrogate agonist.

Publication types

Editorial

MeSH terms

Antibodies, Bispecific*
Cytokines
Humans
Protein Engineering
Single-Domain Antibodies*

Substances

Cytokines
Antibodies, Bispecific
Single-Domain Antibodies