Recent findings on drug hypersensitivity in children

Mara Morelo Rocha Felix; Fábio Chigres Kuschnir; José Laerte Boechat; Mariana Castells

doi:10.3389/falgy.2024.1330517

Recent findings on drug hypersensitivity in children

Front Allergy. 2024 Feb 7:5:1330517. doi: 10.3389/falgy.2024.1330517. eCollection 2024.

Authors

Mara Morelo Rocha Felix¹, Fábio Chigres Kuschnir², José Laerte Boechat^{3

4}, Mariana Castells⁵

Affiliations

¹ Department of General Medicine, School of Medicine and Surgery, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
² Department of Pediatrics, Faculty of Medicine, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
³ Clinical Immunology Service, Internal Medicine Department, Faculty of Medicine, Universidade Federal Fluminense, Niterói, Brazil.
⁴ Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
⁵ Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.

Abstract

Drug hypersensitivity reactions (DHR) in children have a significant impact on clinical practice and public health. Both under-diagnosis (due to under-reporting) and over-diagnosis (due to the overuse of the term "allergy") are potential issues. The aim of this narrative review is to describe the most recent findings of DHR in children/adolescents and gaps regarding epidemiology, antibiotic allergy, antiepileptic hypersensitivity, vaccine allergy, and severe cutaneous adverse reactions (SCAR) in this age group.

Keywords: Stevens-Johnson syndrome; allergy; antibiotic; children; drug hypersensitivity; severe cutaneous adverse drug reactions; toxic epidermal necrolysis; vaccines.

Publication types

Review

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.