Fateful fat: Intra-pancreatic lipids cause pancreatic cancer

Cell Rep Med. 2024 Feb 20;5(2):101428. doi: 10.1016/j.xcrm.2024.101428.

Abstract

In a Mendelian randomization and prospective cohort study,1 intra-pancreatic fat increases the risk of pancreatic cancer. This provides persuasive human evidence of causal relation between lipids and cancer in the pancreas, which confirms a prediction of the PANDORA hypothesis.

MeSH terms

  • Humans
  • Lipids
  • Pancreas*
  • Pancreatic Neoplasms* / epidemiology
  • Pancreatic Neoplasms* / etiology
  • Prospective Studies

Substances

  • Lipids