Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse probability of treatment weighting analysis

Hang-Hang Ni; Zhan Lu; Cheng-Lei Yang; Yu-Ting Lv; Chun-Xiu Lu; Bang-De Xiang

doi:10.1371/journal.pntd.0011987

Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse probability of treatment weighting analysis

PLoS Negl Trop Dis. 2024 Feb 21;18(2):e0011987. doi: 10.1371/journal.pntd.0011987. eCollection 2024 Feb.

Authors

Hang-Hang Ni^{1

2}, Zhan Lu¹, Cheng-Lei Yang¹, Yu-Ting Lv¹, Chun-Xiu Lu¹, Bang-De Xiang^{1

3}

Affiliations

¹ Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, People's Republic of China.
² Department of Hepatobiliary Surgery, Zhongshan City People's Hospital, Zhongshan, People's Republic of China.
³ Key Laboratory of Early Prevention and Treatment for Regional High-Frequency Tumors, Ministry of Education, Nanning, People's Republic of China.

Abstract

Background: We examined the impact of the Clonorchis sinensis (C. sinensis) infection on the survival outcomes of spontaneous rupture Hepatocellular Carcinoma (srHCC) patients undergoing hepatectomy.

Methods: Between May 2013 and December 2021, 157 consecutive srHCC patients who underwent hepatectomy were divided into an no C. sinensis group (n = 126) and C. sinensis group (n = 31). To adjust for differences in preoperative characteristics an inverse probability of treatment weighting (IPTW) analysis was done, using propensity scores. Overall survival (OS) and recurrence-free survival (RFS) were compared before and after IPTW. Multivariate Cox regression analysis was performed to determine whether the C. sinensis infection was an independent prognostic factor after IPTW.

Results: In original cohort, the no C. sinensis group did not show a survival advantage over the C. sinensis group. After IPTW adjustment, the median OS for the C. sinensis group was 9 months, compared to 29 months for the no C. sinensis group. C. sinensis group have worse OS than no C. sinensis group (p = 0.024), while it did not differ in RFS(p = 0.065). The multivariate Cox regression analysis showed that C. sinensis infection and lower age were associated with worse OS.

Conclusions: The C. sinensis infection has an adverse impact on os in srHCC patients who underwent hepatectomy.

Copyright: © 2024 Ni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

MeSH terms

Animals
Carcinoma, Hepatocellular* / pathology
Carcinoma, Hepatocellular* / surgery
Clonorchiasis* / complications
Clonorchiasis* / surgery
Clonorchis sinensis*
Humans
Liver Neoplasms* / pathology
Liver Neoplasms* / surgery
Prognosis
Propensity Score
Retrospective Studies
Rupture, Spontaneous / complications
Rupture, Spontaneous / surgery

Grants and funding

BDX received the financial support from the National Natural Science Foundation of China (grant no. 81960450), the National Major Special Science and Technology Project (grant no. 2017ZX10203207). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.