Elastofibromatous changes in giant cell fibroma and amalgam tattoo: Unusual findings in common oral lesions

J Cutan Pathol. 2024 May;51(5):348-352. doi: 10.1111/cup.14603. Epub 2024 Feb 21.

Abstract

Several cases of elastofibromatous lesion affecting the oral mucosa have been reported. Clinically, these lesions may appear as small exophytic lesions or less often as white lesions. Therefore, fibrous hyperplasia and leukoplakia are not uncommonly considered in clinical differential diagnosis. Microscopically, elastic and fibrous connective tissue deposition is seen. Rarely, elastofibromatous changes can be detected when assessing intraoral lesions, including cysts, salivary gland neoplasms, and epithelial dysplasia. Here we report two oral lesions showing elastofibromatous changes, expanding their clinicopathological spectrum. The first case was a 46-year-old man with a history of asymptomatic nodular lesion on the palate 1 year ago, diagnosed as giant cell fibroma with elastofibromatous changes. The second case was a 79-year-old woman who presented a pigmented and mildly symptomatic lesion on the mandibular alveolar mucosa several months ago, diagnosed as amalgam tattoo associated with elastofibromatous changes.

Keywords: amalgam tattoo; elastofibromatous changes; giant cell fibroma; oral pathology; pigmented lesion.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Fibroma* / diagnosis
  • Fibroma* / pathology
  • Giant Cells / pathology
  • Humans
  • Male
  • Middle Aged
  • Mouth Mucosa / pathology
  • Pigmentation Disorders* / pathology
  • Tattooing*