Nafamostat Mesylate for the Hypercoagulable State of SARS-CoV-2 With Renal Replacement Therapy: A Case Report

Cureus. 2024 Jan 20;16(1):e52641. doi: 10.7759/cureus.52641. eCollection 2024 Jan.

Abstract

Being a dialysis patient is one of the risks for severe coronavirus disease 2019 (COVID-19) cases. In addition, there have been many reports of coagulation abnormalities in severe COVID-19 cases; these also make dialysis management more difficult. In this study, we report a case of severe COVID-19 in a hemodialysis patient who had coagulation in the dialysis circuit with unfractionated heparin (UFH), which could be managed without intracircuit obstruction when nafamostat mesylate (NM) was used in combination with unfractionated heparin.

Keywords: continuous renal replacement therapy (crrt); covid-19; critical emergency medicine; heparin; hypercoagulation; intensive care unit; nafamostat; non-fractioned heparin; renal replacement therapy (rrt); thrombosis.

Publication types

  • Case Reports