Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis

Hélène Duparc; Delphine Muller; Laure Gilles; Agathe L Chédeville; Mira El Khoury; Rose Guignard; Najet Debili; Monika Wittner; Alexandre Kauskot; Florence Pasquier; Iléana Antony-Debré; Caroline Marty; William Vainchenker; Isabelle Plo; Hana Raslova

doi:10.1038/s41375-024-02170-5

Deregulation of the p19/CDK4/CDK6 axis in Jak2^V617F megakaryocytes accelerates the development of myelofibrosis

Leukemia. 2024 Apr;38(4):898-902. doi: 10.1038/s41375-024-02170-5. Epub 2024 Feb 20.

Authors

Hélène Duparc^{1

2

3

4}, Delphine Muller^#^{1

2

3}, Laure Gilles^#^{1

2

3}, Agathe L Chédeville^{1

2

3

4}, Mira El Khoury⁵, Rose Guignard^{1

2

3

4}, Najet Debili^{1

2

3}, Monika Wittner^{1

2

3}, Alexandre Kauskot⁶, Florence Pasquier^{1

2

7}, Iléana Antony-Debré^{1

2

3}, Caroline Marty^{1

2

3}, William Vainchenker^{1

2

3}, Isabelle Plo^{1

2

3}, Hana Raslova^{8

9

10}

Affiliations

¹ INSERM, UMR1287, Gustave Roussy, Equipe labellisée Ligue Nationale Contre le Cancer, Villejuif, France.
² Université Paris-Saclay, Gif-sur-Yvette, Villejuif, France.
³ Gustave Roussy, Villejuif, France.
⁴ Université Paris Cité, Paris, France.
⁵ INSERM UMRS 938, PARIS, Sorbonne Université, Centre de Recherche Saint- Antoine, AP-HP, Hôpital Saint-Antoine, Paris, France.
⁶ INSERM U1176, Hemostasis, Inflammation & Thrombosis (HITh), Université Paris-Saclay, Le Kremlin-Bicêtre, France.
⁷ Département d'Hématologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
⁸ INSERM, UMR1287, Gustave Roussy, Equipe labellisée Ligue Nationale Contre le Cancer, Villejuif, France. hana.raslova@gustaveroussy.fr.
⁹ Université Paris-Saclay, Gif-sur-Yvette, Villejuif, France. hana.raslova@gustaveroussy.fr.
¹⁰ Gustave Roussy, Villejuif, France. hana.raslova@gustaveroussy.fr.

^# Contributed equally.

PMID: 38378843
DOI: 10.1038/s41375-024-02170-5

No abstract available

MeSH terms

Cyclin-Dependent Kinase 4 / genetics
Cyclin-Dependent Kinase 6 / genetics
Humans
Janus Kinase 2 / genetics
Megakaryocytes
Myeloproliferative Disorders*
Primary Myelofibrosis* / genetics

Substances

CDK4 protein, human
CDK6 protein, human
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
Janus Kinase 2
CDKN2D protein, human