Germline CHEK2 mutations in patients with myeloid neoplasms

Lucie Freiman; Lise Larcher; Giulia Tueur; Nadia Vasquez; Mélanie Da Costa; Matthieu Duchmann; Emmanuel Raffoux; Lionel Adès; Pierre Fenaux; Jean Soulier; Nicolas Duployez; Emmanuelle Clappier; Marie Sébert

doi:10.1038/s41375-024-02179-w

Germline CHEK2 mutations in patients with myeloid neoplasms

Leukemia. 2024 Apr;38(4):908-911. doi: 10.1038/s41375-024-02179-w. Epub 2024 Feb 20.

Authors

Lucie Freiman^#^{1

2}, Lise Larcher^#^{1

3

4}, Giulia Tueur³, Nadia Vasquez³, Mélanie Da Costa³, Matthieu Duchmann^{1

3

4}, Emmanuel Raffoux², Lionel Adès^{1

2

4}, Pierre Fenaux^{1

2

4}, Jean Soulier^{1

3

4}, Nicolas Duployez^{1

3

5}, Emmanuelle Clappier^{1

3

4}, Marie Sébert^{6

7

8}

Affiliations

¹ Institut de Recherche Saint-Louis (IRSL), Université Paris Cité, 75010, Paris, France.
² Clinical Hematology Departments, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
³ Hematology Laboratory, Saint-Louis Hospital, APHP, Paris, France.
⁴ INSERM U944/CNRS UMR7212, Paris, France.
⁵ Hematology Laboratory, Unité 1277-Cancer Heterogeneity Plasticity and Resistance to Therapies (CANTHER), Centre Hospitalier Universitaire (CHU) de Lille, University of Lille, Lille, France.
⁶ Institut de Recherche Saint-Louis (IRSL), Université Paris Cité, 75010, Paris, France. marie.sebert@aphp.fr.
⁷ Clinical Hematology Departments, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France. marie.sebert@aphp.fr.
⁸ INSERM U944/CNRS UMR7212, Paris, France. marie.sebert@aphp.fr.

^# Contributed equally.

PMID: 38378842
DOI: 10.1038/s41375-024-02179-w

No abstract available

MeSH terms

Checkpoint Kinase 2 / genetics
Genetic Predisposition to Disease
Germ Cells
Germ-Line Mutation
Humans
Neoplasms*

Substances

CHEK2 protein, human
Checkpoint Kinase 2