A noncoding role of coding mRNA in monogenic olfactory receptor choice

Yue Hao; Kang-Ying Qian; Qian Li

doi:10.1016/j.tins.2024.02.004

A noncoding role of coding mRNA in monogenic olfactory receptor choice

Trends Neurosci. 2024 Mar;47(3):167-169. doi: 10.1016/j.tins.2024.02.004. Epub 2024 Feb 19.

Authors

Yue Hao¹, Kang-Ying Qian¹, Qian Li²

Affiliations

¹ Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China; Department of Anatomy and Physiology, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
² Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China; Department of Anatomy and Physiology, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: liqian@shsmu.edu.cn.

PMID: 38378395
DOI: 10.1016/j.tins.2024.02.004

Abstract

In a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.

Keywords: 3D genome structure; development; enhancer hub; epigenetics; histone modifications; nuclear organization.

MeSH terms

Humans
Olfactory Receptor Neurons* / metabolism
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, Odorant* / genetics
Receptors, Odorant* / metabolism

Substances

Receptors, Odorant
RNA, Messenger

Abstract

MeSH terms

Substances

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