Non-coding RNAs in gynecologic cancer

Arezoo Solati; Sina Thvimi; Seyyed Hossein Khatami; Zahra Shabaninejad; Yalda Malekzadegan; Mehdi Alizadeh; Pegah Mousavi; Mortaza Taheri-Anganeh; Damoun Razmjoue; Sedigheh Bahmyari; Hojat Ghasemnejad-Berenji; Asma Vafadar; Elahe Soltani Fard; Hassan Ghasemi; Ahmad Movahedpour

doi:10.1016/j.cca.2023.117618

Non-coding RNAs in gynecologic cancer

Clin Chim Acta. 2023 Nov 1:551:117618. doi: 10.1016/j.cca.2023.117618. Epub 2023 Oct 30.

Authors

Affiliations

¹ Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
² Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
³ Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
⁵ Saveh University of Medical Sciences, Saveh, Iran.
⁶ Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
⁷ Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
⁸ Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁹ Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
¹⁰ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
¹¹ Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
¹² Abadan University of Medical Sciences, Abadan, Iran. Electronic address: h.ghasemi@abadanums.ac.ir.
¹³ Behbahan Faculty of Medical Sciences, Behbahan, Iran. Electronic address: a.movahed14@behums.ac.ir.

PMID: 38375624
DOI: 10.1016/j.cca.2023.117618

Abstract

The term "gynecologic cancer" pertains to neoplasms impacting the reproductive tissues and organs of women encompassing the endometrium, vagina, cervix, uterus, vulva, and ovaries. The progression of gynecologic cancer is linked to various molecular mechanisms. Historically, cancer research primarily focused on protein-coding genes. However, recent years have unveiled the involvement of non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs (LncRNAs), and circular RNAs, in modulating cellular functions within gynecological cancer. Substantial evidence suggests that ncRNAs may wield a dual role in gynecological cancer, acting as either oncogenic or tumor-suppressive agents. Numerous clinical trials are presently investigating the roles of ncRNAs as biomarkers and therapeutic agents. These endeavors may introduce a fresh perspective on the diagnosis and treatment of gynecological cancer. In this overview, we highlight some of the ncRNAs associated with gynecological cancers.

Keywords: Biomarker; Cancer; Gynecology; Non-coding RNAs.

Publication types

Review

MeSH terms

Female
Gynecology*
Humans
MicroRNAs* / genetics
Neoplasms* / drug therapy
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics

Substances

RNA, Untranslated
MicroRNAs
RNA, Long Noncoding