Recent advances in senescence-associated secretory phenotype and osteoporosis

Haonan Fan; Zhi Qiao; Jitian Li; Guowei Shang; Chunfeng Shang; Songfeng Chen; Zikuan Leng; Huifang Su; Hongwei Kou; Hongjian Liu

doi:10.1016/j.heliyon.2024.e25538

Recent advances in senescence-associated secretory phenotype and osteoporosis

Heliyon. 2024 Feb 8;10(4):e25538. doi: 10.1016/j.heliyon.2024.e25538. eCollection 2024 Feb 29.

Authors

Affiliations

¹ Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
² Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital)/Henan Institute of Orthopedic and Traumatology, Luoyang 471000, China.

Abstract

The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age. The senescence-associated secretory phenotype (SASP), an essential cellular senescence hallmark, is an important mechanism connecting cellular senescence to osteoporosis. This review describes in detail the characteristics of SASPs and their regulatory agencies, and shed fresh light on how SASPs from different senescent cells contribute to osteoporosis development. Furthermore, we summarized various innovative therapy techniques that target SASPs to lower the burden of osteoporosis in the elderly and discussed the potential challenges of SASPs-based therapy for osteoporosis as a new clinical trial.

Keywords: Cellular senescence; Osteoporosis; Senescence-associated secretory phenotype (SASP).

Publication types

Review