A Rare Presentation of Collision Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma Treated with R-CHOP and Adjuvant Radiation Therapy

Batoul Mazraani; Batoul Nasser; Bailey Loving; Zachary N Awad; Thomas J Quinn

doi:10.7759/cureus.52630

A Rare Presentation of Collision Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma Treated with R-CHOP and Adjuvant Radiation Therapy

Cureus. 2024 Jan 20;16(1):e52630. doi: 10.7759/cureus.52630. eCollection 2024 Jan.

Authors

Batoul Mazraani¹, Batoul Nasser², Bailey Loving³, Zachary N Awad¹, Thomas J Quinn³

Affiliations

¹ Radiation Oncology, Oakland University William Beaumont School of Medicine, Rochester Hills, USA.
² Radiation Oncology, University of Michigan, Ann Arbor, USA.
³ Radiation Oncology, Beaumont Hospital, Royal Oak, USA.

Abstract

Collision tumors are rare neoplasms displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. There are currently no guidelines for the recommended treatment for such rare collision cases. We herein report a unique case of a 45-year-old female who presented with a left-sided palpable inguinal lymph node. A subsequent excisional biopsy yielded a diagnosis of collision lymphoma (CL) of nodular sclerosing Hodgkin lymphoma (HL) and germinal center diffuse large B-cell lymphoma (DLBCL). This case report highlights the challenges in managing CL and the potential efficacy of cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab regimen (R-CHOP) and adjuvant radiation therapy (RT) in treating this rare condition. Our goal is to enrich the literature with our case on CL in an attempt to progress to a path of ultimately establishing a definitive treatment approach to CL of DLBCL and HL.

Keywords: adjuvant radiation therapy; collision tumor; diffuse large b-cell lymphoma; hodgkin lymphoma; malignant lymphoma; non-hodgkin lymphoma; r-chop.

Publication types

Case Reports