Susceptibility of healthcare personnel with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) hybrid immunity to XBB lineage reinfection

Karissa A Whiting; Rebecca Guest; Venkatraman E Seshan; Mini Kamboj

doi:10.1017/ice.2023.282

Susceptibility of healthcare personnel with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) hybrid immunity to XBB lineage reinfection

Infect Control Hosp Epidemiol. 2024 Jun;45(6):781-784. doi: 10.1017/ice.2023.282. Epub 2024 Feb 20.

Authors

Karissa A Whiting¹, Rebecca Guest², Venkatraman E Seshan¹, Mini Kamboj^{3

4

5}

Affiliations

¹ Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
² Employee Health, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Infectious Diseases, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
⁴ Infection Control, Memorial Sloan Kettering Cancer Center, New York, New York.
⁵ Department of Medicine, Joan and Sanford Weill Medical College of Cornell University, New York, New York.

PMID: 38374682
DOI: 10.1017/ice.2023.282

Abstract

Among 8,678 vaccinated healthcare personnel (HCP) with previous coronavirus disease 2019 (COVID-19), by August 28, 2023, 909 (10%) had an infection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) omicron XBB variant. Reinfection risk was comparable irrespective of previous infection type except for the omicron BQ.1 variant. Bivalent vaccination had a protective effect. COVID-19 vaccines remain vital to protect HCP, including those with hybrid immunity.

MeSH terms

Adult
COVID-19 Vaccines / immunology
COVID-19* / immunology
COVID-19* / prevention & control
Female
Health Personnel* / statistics & numerical data
Humans
Male
Middle Aged
Reinfection*
SARS-CoV-2* / immunology

Supplementary concepts

SARS-CoV-2 variants