Development of a digital intervention for psychedelic preparation (DIPP)

Sci Rep. 2024 Feb 19;14(1):4072. doi: 10.1038/s41598-024-54642-4.

Abstract

Psychedelic substances induce profound alterations in consciousness. Careful preparation is therefore essential to limit adverse reactions, enhance therapeutic benefits, and maintain user safety. This paper describes the development of a self-directed, digital intervention for psychedelic preparation. Drawing on elements from the UK Medical Research Council (MRC) framework for developing complex interventions, the design was informed by a four-factor model of psychedelic preparedness, using a person-centred approach. Our mixed-methods investigation consisted of two studies. The first involved interviews with 19 participants who had previously attended a 'high-dose' psilocybin retreat, systematically exploring their preparation behaviours and perspectives on the proposed intervention. The second study engaged 28 attendees of an ongoing psilocybin retreat in co-design workshops, refining the intervention protocol using insights from the initial interviews. The outcome is a co-produced 21-day digital course (Digital Intervention for Psychedelic Preparation (DIPP)), that is organised into four modules: Knowledge-Expectation, Psychophysical-Readiness, Safety-Planning, and Intention-Preparation. Fundamental components of the course include daily meditation practice, supplementary exercises tied to the weekly modules, and mood tracking. DIPP provides a comprehensive and scalable solution to enhance psychedelic preparedness, aligning with the broader shift towards digital mental health interventions.

Keywords: Co-design; Digital intervention; Meditation; Person-centred; Psilocybin; Psychedelic preparedness; Psychedelic therapy; Psychedelics; Qualitative.

MeSH terms

  • Consciousness
  • Hallucinogens* / pharmacology
  • Humans
  • Mental Health
  • Pentamidine / analogs & derivatives*
  • Psilocybin / pharmacology

Substances

  • Hallucinogens
  • Psilocybin
  • 1,3-di(4-imidazolinophenoxyl)propane
  • Pentamidine