Long-term recurrence-free survival following pancreatic surgery with HIPEC treatment for locally advanced pancreatic adenocarcinoma

BMJ Case Rep. 2024 Feb 19;17(2):e258626. doi: 10.1136/bcr-2023-258626.

Abstract

More than 5 years previous to this report, a female patient in her 60s underwent oncological left-sided pancreatic resection and adrenalectomy including splenectomy for locally advanced pancreatic adenocarcinoma (PDAC), recommended by a multidisciplinary tumour board (MDT). Additionally, she was treated with gemcitabine-containing hyperthermic intraperitoneal chemotherapy (HIPEC) for 60 minutes in the framework of a clinical trial (PanHIPEC), aiming to determine the safety and feasibility (not efficacy) of this approach. Following the postoperative MDT recommendation, she subsequently received adjuvant chemotherapy consisting of six cycles of gemcitabine and cisplatin for a histopathologically confirmed PDAC of the pancreatic tail with infiltration of the left-sided adrenal gland (pT3, pN1 (3/16), cM0, L0, V0, Pn1, R0, G2). Five years and five months after pancreatic surgery and HIPEC, the patient has no signs of tumour recurrence as determined by follow-up examination including CT scan and CA19-9 tumour marker serology.

Keywords: cancer intervention; drug therapy related to surgery; pancreatic cancer; surgical oncology.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma* / drug therapy
  • Adenocarcinoma* / surgery
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Female
  • Gemcitabine
  • Humans
  • Hyperthermic Intraperitoneal Chemotherapy
  • Neoplasm Recurrence, Local / drug therapy
  • Pancreatic Neoplasms* / drug therapy
  • Pancreatic Neoplasms* / surgery

Substances

  • Gemcitabine