A new physiologic model for dynamic process of Creatine Kinase (CK) after acute myocardial infarction is proposed. The fundamental hypotheses are tested. The new model is better than the log-normal model in goodness of fit. With this new model, the infarct size of complicated cases with double or multiple peak CK curve can be estimated as well as that of uncomplicated cases. To estimate parameters, a nomographic algorithm and a computer program have been designed. In most cases, the initial values for parameters estimated with Marquardt's method can be determined from individual CK data.