Who Should Receive Immunotherapy for Advanced Gastroesophageal Cancer?

Curr Treat Options Oncol. 2024 Apr;25(4):496-509. doi: 10.1007/s11864-024-01189-1. Epub 2024 Feb 19.

Abstract

This paper shines a light on the exciting progress being made in using immunotherapy to treat advanced gastroesophageal cancers. The positive results from trials using drugs like Pembrolizumab and Nivolumab are certainly encouraging and open new possibilities for treating this challenging disease. However, it is clear that we still have a lot to learn about how to predict which patients will benefit most from these treatments. The exploration of combining therapies and using machine learning to guide treatment shows promise. Moving forward, it is crucial that researchers and healthcare professionals continue to work together, sharing knowledge and findings to continue the advancements in this important area.

Keywords: Gastro-esophageal cancers; Immunotherapy; PD-1 Inhibitors; PD-L1 expression.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • B7-H1 Antigen
  • Esophageal Neoplasms* / drug therapy
  • Humans
  • Immunotherapy / methods
  • Nivolumab / therapeutic use
  • Stomach Neoplasms* / drug therapy

Substances

  • Antibodies, Monoclonal
  • Nivolumab
  • B7-H1 Antigen