A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas' disease

Abstract

The drug discovery pipeline for leishmaniasis and trypanosomiasis has been filling with novel chemical entities with known mechanisms of action. González et al. and Braillard et al. report a cytochrome bc₁ complex inhibitor as another promising preclinical candidate for visceral leishmaniasis (VL) and, in combination with benznidazole, for chronic Chagas' disease (CCD).

Keywords: chronic Chagas’ disease; cytochrome b; drug combinations; visceral leishmaniasis.