Passive trapping of biomolecules in hotspots with all-dielectric terahertz metamaterials

Biosens Bioelectron. 2024 May 1:251:116126. doi: 10.1016/j.bios.2024.116126. Epub 2024 Feb 12.

Abstract

Electromagnetic metamaterials feature the capability of squeezing photons into hotspot regions of high intensity near-field enhancement for strong light-matter interaction, underpinning the next generation of emerging biosensors. However, randomly dispersed biomolecules around the hotspots lead to weak interactions. Here, we demonstrate an all-silicon dielectric terahertz metamaterial sensor design capable of passively trapping biomoleculars into the resonant cavities confined with powerful electric field. Specifically, multiple controllable high-quality factor resonances driven by bound states in the continuum (BIC) are realized by employing longitudinal symmetry breaking. The dielectric metamaterial sensor with nearly 15.2 experimental figure-of-merit enabling qualitative and quantitative identification of different amino acids by delivering biomolecules to the hotspots for strong light-matter interactions. It is envisioned that the presented strategy will enlighten high-performance meta-sensors design from microwaves to visible frequencies, and serve as a potential platform for microfluidic sensing, biomolecular capture, and sorting devices.

Keywords: All-dielectric metamaterials; Biosensors; Bound states in the continuum; Terahertz.

MeSH terms

  • Amino Acids
  • Biosensing Techniques*
  • Cell Movement
  • Electricity
  • Microfluidics

Substances

  • Amino Acids