The reckoning of chromosomal instability: past, present, future

Andrew Lynch; Shermineh Bradford; Mark E Burkard

doi:10.1007/s10577-024-09746-y

The reckoning of chromosomal instability: past, present, future

Chromosome Res. 2024 Feb 17;32(1):2. doi: 10.1007/s10577-024-09746-y.

Authors

Andrew Lynch^{1

2

3}, Shermineh Bradford^{1

2

3}, Mark E Burkard^{4

5

6}

Affiliations

¹ UW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.
² McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA.
³ Division of Hematology/Oncology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
⁴ UW Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. mburkard@wisc.edu.
⁵ McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA. mburkard@wisc.edu.
⁶ Division of Hematology/Oncology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. mburkard@wisc.edu.

PMID: 38367036
DOI: 10.1007/s10577-024-09746-y

Abstract

Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we review measures of CIN through its rise as a field, discuss considerations for its measurement, and look forward to future quantification of CIN.

Keywords: Aneuploidy; CIN; Cancer; Cytogenetics; Genomic instability; Quantitative measures.

The reckoning of chromosomal instability: past, present, future

Authors

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Abstract

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