A case of tachycardia-induced acute kidney injury by renal hypouricemia

Gaku Izumi; Atsuhito Takeda; Takayuki Okamoto; Satoru Shida; Hirotaka Matsuo

doi:10.1016/j.jccase.2023.10.009

A case of tachycardia-induced acute kidney injury by renal hypouricemia

J Cardiol Cases. 2023 Nov 10;29(2):59-62. doi: 10.1016/j.jccase.2023.10.009. eCollection 2024 Feb.

Authors

Gaku Izumi¹, Atsuhito Takeda¹, Takayuki Okamoto¹, Satoru Shida², Hirotaka Matsuo³

Affiliations

¹ Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
² Department of Pediatrics, Ebetsu City Hospital, Ebetsu, Japan.
³ Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.

Abstract

Idiopathic renal hypouricemia is an autosomal recessive hereditary disease, characterized by hypouricemia and high renal fractional excretion of uric acid, and can be complicated by acute kidney injury after anaerobic exercise. However, no report has suggested tachycardia-induced acute kidney injury complicated with renal hypouricemia. We herein report the case of a 12-year-old female with tachycardia-induced acute kidney injury complicated with renal hypouricemia. It is an important issue that the tachycardias and acute kidney injury due to renal hypouricemia can be deteriorating factors for each other through the reactive oxygen species.

Learning objective: Renal hypouricemia is rare, with a frequency of 0.2-0.4 %, but is often overlooked and can produce acute kidney injury after exercise. Tachyarrhythmia can be an inducer of acute kidney injury in patients with renal hypouricemia.

Keywords: Acute kidney injury; Atrial tachyarrhythmia; Renal hypouricemia.

Publication types

Case Reports