RNA therapeutics for respiratory diseases

Prog Mol Biol Transl Sci. 2024:203:257-271. doi: 10.1016/bs.pmbts.2023.12.021. Epub 2024 Jan 25.

Abstract

It has become increasingly common to utilize RNA treatment to treat respiratory illnesses. Experimental research on both people and animals has advanced quickly since the turn of the twenty-first century in an effort to discover a treatment for respiratory ailments that could not be accomplished with earlier techniques, specifically in treating prevalent respiratory diseases such as lung cancer, chronic obstructive pulmonary disease (COPD), respiratory infections caused by viruses, and asthma. This chapter has provided a comprehensive overview of the scientific evidence in applying RNA therapy to treat respiratory diseases. The chapter describes the development of this therapy for respiratory diseases. At the same time, the types of RNA therapy for respiratory diseases have been highlighted. In addition, the mechanism of this therapy for respiratory diseases has also been covered. These insights are indispensable if this therapy is to be developed widely.

Keywords: Chronic respiratory diseases; RNA therapeutics; RNA-based therapeutics; Viral respiratory diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Asthma* / genetics
  • Asthma* / therapy
  • Humans
  • Pulmonary Disease, Chronic Obstructive* / genetics
  • Pulmonary Disease, Chronic Obstructive* / therapy
  • RNA
  • Respiratory Tract Infections* / therapy
  • Viruses*

Substances

  • RNA