Arming up against Omicron subvariants

Daniel M Altmann; Rosemary J Boyton

doi:10.1016/j.chom.2024.01.010

Arming up against Omicron subvariants

Cell Host Microbe. 2024 Feb 14;32(2):147-148. doi: 10.1016/j.chom.2024.01.010.

Authors

Daniel M Altmann¹, Rosemary J Boyton²

Affiliations

¹ Department of Immunology and Inflammation, Faculty of Medicine, Imperial College, London, UK. Electronic address: d.altmann@imperial.ac.uk.
² Department of Infectious Disease, Faculty of Medicine, Imperial College, London, UK.

PMID: 38359794
DOI: 10.1016/j.chom.2024.01.010

Abstract

The rapid evolution of COVID-19 Omicron variants is driven by evasion of neutralizing antibodies. Breakthrough infections are common, even in highly vaccinated populations, making it vital to understand immune cross-protective repertoires to variants. Two studies in this issue show that the primed T cell repertoire comprises strong cross-recognition of current variants.

MeSH terms

Antibodies, Neutralizing*
Antibodies, Viral
COVID-19*
Humans

Substances

Antibodies, Neutralizing
Antibodies, Viral