Telomerase misbehaves after a breakup

Science. 2024 Feb 16;383(6684):702-703. doi: 10.1126/science.adn7791. Epub 2024 Feb 15.

Authors

Nausica Arnoult¹, Thomas R Cech²

Affiliations

¹ Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
² Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.

PMID: 38359118
DOI: 10.1126/science.adn7791

Abstract

Suppressing telomerase action at broken DNA preserves genome integrity.

MeSH terms

DNA Breaks, Double-Stranded*
DNA Repair*
Humans
Telomerase* / genetics
Telomerase* / metabolism
Telomere* / genetics
Telomere* / metabolism

Substances

Telomerase