17β-estradiol biosensors based on different bioreceptors and their applications

Xinyi Wang; Fanli Kong; Yaoyao Liu; Shiya Lv; Kui Zhang; Shutong Sun; Juntao Liu; Mixia Wang; Xinxia Cai; Hongyan Jin; Shi Yan; Jinping Luo

doi:10.3389/fbioe.2024.1347625

17β-estradiol biosensors based on different bioreceptors and their applications

Front Bioeng Biotechnol. 2024 Jan 31:12:1347625. doi: 10.3389/fbioe.2024.1347625. eCollection 2024.

Authors

Xinyi Wang^{1

2}, Fanli Kong^{1

2}, Yaoyao Liu^{1

2}, Shiya Lv^{1

2}, Kui Zhang^{1

2}, Shutong Sun^{1

2}, Juntao Liu^{1

2}, Mixia Wang^{1

2}, Xinxia Cai^{1

2}, Hongyan Jin³, Shi Yan⁴, Jinping Luo^{1

2}

Affiliations

¹ State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China.
² School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China.
³ Obstetrics and Gynecology Department, Peking University First Hospital, Beijing, China.
⁴ Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China.

Abstract

17β-Estradiol (E2) is a critical sex steroid hormone, which has significant effects on the endocrine systems of both humans and animals. E2 is also believed to play neurotrophic and neuroprotective roles in the brain. Biosensors present a powerful tool to detect E2 because of their small, efficient, and flexible design. Furthermore, Biosensors can quickly and accurately obtain detection results with only a small sampling amount, which greatly meets the detection of the environment, food safety, medicine safety, and human body. This review focuses on previous studies of biosensors for detecting E2 and divides them into non-biometric sensors, enzyme biosensors, antibody biosensors, and aptamer biosensors according to different bioreceptors. The advantages, disadvantages, and design points of various bioreceptors for E2 detection are analyzed and summarized. Additionally, applications of different bioreceptors of E2 detection are presented and highlight the field of environmental monitoring, food and medicine safety, and disease detection in recent years. Finally, the development of E2 detection by biosensor is prospected.

Keywords: 17β-estradiol detection; aptamer biosensor; electrochemistry; immunosensor; nanomaterials.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported sponsored by the National Natural Science Foundation of China (Nos. 62121003, 61960206012, T2293731, T2293730, 62171434, 61975206, 61971400 and 61973292), the National Key Research and Development Program of China (Nos. 2022YFB3205602, 2022YFC2402501), Major Program of Scientific and Technical Innovation 2030 (No. 2021ZD02016030) and Beijing Municipal Administration of Hospitals Incubating Program (No. PX2021044).