Metabolic dysregulation of lymphocytes in autoimmune diseases

Shuyi Wang; Niansheng Yang; Hui Zhang

doi:10.1016/j.tem.2024.01.005

Metabolic dysregulation of lymphocytes in autoimmune diseases

Trends Endocrinol Metab. 2024 Feb 13:S1043-2760(24)00019-5. doi: 10.1016/j.tem.2024.01.005. Online ahead of print.

Authors

Shuyi Wang¹, Niansheng Yang¹, Hui Zhang²

Affiliations

¹ Department of Rheumatology and Clinical Immunology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
² Department of Rheumatology and Clinical Immunology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; Institute of Precision Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zhangh656@mail.sysu.edu.cn.

PMID: 38355391
DOI: 10.1016/j.tem.2024.01.005

Abstract

Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases.

Keywords: B cells; T cells; autoimmune diseases; immunometabolism; lymphocytes; rheumatoid arthritis; systemic lupus erythematosus.

Publication types

Review