MicroRNA biosensors for detection of glioblastoma

Mehdi Fattahi; Mohadese Maghsudlu; Masoumeh Razipour; Ahmad Movahedpour; Mohsen Ghadami; Mehdi Alizadeh; Seyyed Hossein Khatami; Mortaza Taheri-Anganeh; Ehsan Ghasemi; Hassan Ghasemi; Saleh Aiiashi; Elham Ghadami

doi:10.1016/j.cca.2024.117829

MicroRNA biosensors for detection of glioblastoma

Clin Chim Acta. 2024 Mar 15:556:117829. doi: 10.1016/j.cca.2024.117829. Epub 2024 Feb 13.

Affiliations

¹ Institute of Research and Development, Duy Tan University, Da Nang, Vietnam; School of Engineering & Technology, Duy Tan University, Da Nang, Vietnam.
² Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
³ Behbahan Faculty of Medical Sciences, Behbahan, Iran.
⁴ Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
⁶ Abadan University of Medical Sciences, Abadan, Iran.
⁷ Abadan University of Medical Sciences, Abadan, Iran. Electronic address: medical.bitechnology2@yahoo.com.
⁸ Abadan University of Medical Sciences, Abadan, Iran. Electronic address: s.aiiashi65@gmail.com.
⁹ Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: medical.bitechnology3@yahoo.com.

PMID: 38355000
DOI: 10.1016/j.cca.2024.117829

Abstract

Glioblastoma (GBM) is the most common type of malignant brain tumor.The discovery of microRNAs and their unique properties have made them suitable tools as biomarkers for cancer diagnosis, prognosis, and evaluation of therapeutic response using different types of nanomaterials as sensitive and specific biosensors. In this review, we discuss microRNA-based electrochemical biosensing systems and the use of nanoparticles in the evolving development of microRNA-based biosensors in glioblastoma.

Keywords: Biomarker; Cancer; Diagnosis; microRNA.

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Biosensing Techniques*
Electrochemical Techniques
Glioblastoma* / diagnosis
Glioblastoma* / genetics
Glioblastoma* / therapy
Humans
MicroRNAs* / genetics
Nanoparticles*
Nanostructures* / chemistry

Substances

MicroRNAs
Biomarkers, Tumor