Host-microbial crosstalk relies on "tuft" love

Stefania De Santis; Theresa T Pizarro

doi:10.1016/j.immuni.2024.01.016

Host-microbial crosstalk relies on "tuft" love

Immunity. 2024 Feb 13;57(2):195-197. doi: 10.1016/j.immuni.2024.01.016.

Authors

Stefania De Santis¹, Theresa T Pizarro²

Affiliations

¹ Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
² Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: theresa.pizarro@case.edu.

PMID: 38354697
DOI: 10.1016/j.immuni.2024.01.016

Abstract

How commensals influence intestinal immunity is incompletely understood. In this issue of Immunity, Eshleman et al. demonstrate that microbiota-derived butyrate restrains tuft cell development via HDAC3 modulation in intestinal epithelial cells, showing how microbial metabolites impact intestinal type 2 immunity.

MeSH terms

Epithelial Cells
Intestinal Mucosa*
Intestines
Love
Microbiota*