Polyether ionophore resistance in a one health perspective

Rikki Franklin Frederiksen; Jannice Schau Slettemeås; Silje Granstad; Karin Lagesen; Mariel G Pikkemaat; Anne Margrete Urdahl; Roger Simm

doi:10.3389/fmicb.2024.1347490

Polyether ionophore resistance in a one health perspective

Front Microbiol. 2024 Jan 29:15:1347490. doi: 10.3389/fmicb.2024.1347490. eCollection 2024.

Authors

Rikki Franklin Frederiksen¹, Jannice Schau Slettemeås¹, Silje Granstad¹, Karin Lagesen¹, Mariel G Pikkemaat², Anne Margrete Urdahl¹, Roger Simm³

Affiliations

¹ Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway.
² Wageningen Food Safety Research, Wageningen University and Research, Wageningen, Netherlands.
³ Department of Biosciences, University of Oslo, Oslo, Norway.

Abstract

Antimicrobial resistance is a major threat to human health and must be approached from a One Health perspective. Use of antimicrobials in animal husbandry can lead to dissemination and persistence of resistance in human pathogens. Polyether ionophores (PIs) have antimicrobial activities and are among the most extensively used feed additives for major production animals. Recent discoveries of genetically encoded PI resistance mechanisms and co-localization of resistance mechanisms against PIs and antimicrobials used in human medicine on transferrable plasmids, have raised concerns that use of PIs as feed additives bear potential risks for human health. This review summarizes the current knowledge on PI resistance and discusses the potential consequences of PI-usage as feed additives in a One Health perspective.

Keywords: anticoccidials; antimicrobial resistance; coccidiostats; growth promoters; one health; polyether ionophore; vancomycin resistance.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This project received funding from the Norwegian Research Council under grant number 333858 and the Netherlands Organization for Health Research and Development ZonMw under grant number 1070132110001 under the umbrella of the JPIAMR—Joint Programming Initiative on Antimicrobial Resistance.