Emerging role of RNA modification and long noncoding RNA interaction in cancer

Liqiong Yang; Lu Tang; Qi Min; Hua Tian; Linwei Li; Yueshui Zhao; Xu Wu; Mingxing Li; Fukuan Du; Yu Chen; Wanping Li; Xiaobing Li; Meijuan Chen; Li Gu; Yuhong Sun; Zhangang Xiao; Jing Shen

doi:10.1038/s41417-024-00734-2

Emerging role of RNA modification and long noncoding RNA interaction in cancer

Cancer Gene Ther. 2024 Feb 14. doi: 10.1038/s41417-024-00734-2. Online ahead of print.

Authors

Liqiong Yang^{1

2

3}, Lu Tang^{1

2

3}, Qi Min^{1

2

3}, Hua Tian^{1

2

3}, Linwei Li⁴, Yueshui Zhao^{1

2

3}, Xu Wu^{1

2

3}, Mingxing Li^{1

2

3}, Fukuan Du^{1

2

3}, Yu Chen^{1

2

3}, Wanping Li^{1

2

3}, Xiaobing Li^{1

2

3}, Meijuan Chen^{1

2

3}, Li Gu^{1

2

3}, Yuhong Sun^{1

2

3}, Zhangang Xiao^{5

6

7}, Jing Shen^{8

9

10}

Affiliations

¹ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.
² Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, China.
³ South Sichuan Institute of Translational Medicine, Luzhou, 646000, China.
⁴ Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
⁵ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China. zhangangxiao@swmu.edu.cn.
⁶ Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, China. zhangangxiao@swmu.edu.cn.
⁷ South Sichuan Institute of Translational Medicine, Luzhou, 646000, China. zhangangxiao@swmu.edu.cn.
⁸ Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China. jingshen@swmu.edu.cn.
⁹ Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou, 646000, China. jingshen@swmu.edu.cn.
¹⁰ South Sichuan Institute of Translational Medicine, Luzhou, 646000, China. jingshen@swmu.edu.cn.

PMID: 38351139
DOI: 10.1038/s41417-024-00734-2

Abstract

RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation and regulation of noncoding RNA, especially lncRNA, play a major role in cancer. Generally, lncRNAs exert tumor-suppressive or oncogenic functions and its dysregulation can promote tumor occurrence and metastasis. In this review, we summarize N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine modifications in lncRNAs. Furthermore, we discuss the relationship between epigenetic RNA modification and lncRNA interaction and cancer progression in various cancers. Therefore, this review gives a comprehensive understanding of the mechanisms by which RNA modification affects the progression of various cancers by regulating lncRNAs, which may shed new light on cancer research and provide new insights into cancer therapy.

Publication types

Review

Abstract

Publication types

Grants and funding