Risk factors associated with intraventricular hemorrhage in very-low-birth-weight premature infants

Childs Nerv Syst. 2024 Jun;40(6):1743-1750. doi: 10.1007/s00381-024-06310-1. Epub 2024 Feb 13.

Abstract

Purpose: To analyze the association between risk factors and severe intraventricular hemorrhage (grade II-IV) in PNB under 1500 g.

Methods: Multicenter, retrospective, analytical, case-control study in PNB under 34 weeks and under 1500 g admitted to the NICU.

Case: PNB with severe intraventricular hemorrhage (grade II-IV). Logistic regression analysis was used to adjust for IVH-associated variables and odds ratios (OR).

Results: A total of 90 PNB files were analyzed, 45 cases and 45 controls. The highest risk factors for severe IVH were lower gestational age (OR 1.3, p < 0.001), perinatal asphyxia (OR 12, p < 0.001), Apgar < 6 at minute 1 and 5 (OR 6.3, p < 0.001).

Conclusion: Lower gestational age, birth asphyxia, Apgar score lower of 6, and respiratory-type factors are associated with increased risk for severe IVH.

Keywords: Intraventricular hemorrhage; Premature newborn; Preterm babies; Risk factors.

Publication types

  • Multicenter Study

MeSH terms

  • Apgar Score
  • Asphyxia Neonatorum / complications
  • Asphyxia Neonatorum / epidemiology
  • Case-Control Studies
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / epidemiology
  • Cerebral Hemorrhage / etiology
  • Cerebral Intraventricular Hemorrhage / complications
  • Cerebral Intraventricular Hemorrhage / diagnostic imaging
  • Cerebral Intraventricular Hemorrhage / epidemiology
  • Cerebral Intraventricular Hemorrhage / etiology
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Premature, Diseases / epidemiology
  • Infant, Premature, Diseases / etiology
  • Infant, Very Low Birth Weight*
  • Male
  • Retrospective Studies
  • Risk Factors